The Embassy of Good Science - User contributions [en]

Theme:30f90943-c3fc-4a8b-b01d-5a66288e3678

2021-07-14T15:49:41Z

0000-0002-3467-1908:

{{Theme
|Theme Type=Good Practices
|Has Parent Theme=Theme:7e07b7fa-793a-4282-a036-6fefe8480b3a
|Title=Preregistration of animal study protocols
|Is About=Preregistration is the act of registering research protocols before conducting the experiments. It enables to state in advance the type of study (exploratory or confirmatory), hypotheses, methodological design and statistical plan that are going to be used.

Preregistration of animal studies belongs to the Open Science movement and enables a comprehensive overview of all (registered) studies, including those that might otherwise remain unpublished. Therefore, it promotes transparency and research rigour.

Although this process is rather common in clinical research, it is not yet standard practice in the preclinical field. According to recent reviews, initiatives are present to promote preregistration of animal studies, but the uptake remains slow [1]

[1] Baker M. Animal registries aim to reduce bias. Nature. 2019;573(7773):297-8, doi:10.1038/d41586-019-02676-4
|Important Because=Preregistration prevents several biases often occurring in preclinical experiments and promote responsible & robust animal research. By reducing these biases, researchers increase the value and reliability of their studies and contribute to better science.

*The overview created by preregistration enables to '''counter publication bias''' by making these studies available regardless of their results.
*Preregistration enables to compare final publications and (pre)registered protocols, which '''increase transparency''' and '''reduce reporting bias''', such as selective outcomes reporting.
*By stating in advance hypotheses and statistical plans, preregistration '''reduces misconducts''' like HARKing (Hypothesis After Results are Known) and p-hacking.
*The free access of study protocols enables to verify which studies are or were conducted and hence permits to '''avoid unnecessary duplication''' of animal studies.
*Most preregistration forms request information linked to internal validity (e.g., randomisation, blinding, sample size calculation), which may impact '''study design robustness and reporting'''.
|Important For=All stakeholders in research
|Has Best Practice=The best practice is to preregister study protocols online in a registry. When describing their study designs, researchers should be as transparent and complete as possible.

To date, only two reliable animal registries are available:[https://preclinicaltrials.eu/ Preclinicaltrials.eu] and the [https://www.animalstudyregistry.org/asr_web/index.action Animal Study Registry].

It is also possible to use general registries, e.g. the Open Science Framework, however the registration forms will not be tailored to animal studies specifically.

If a study could not be preregistered, it is still worthwhile to register its protocol at a later stage; especially if the study could not be published. Although, prospective registration (i.e., registration before the experiments) should be encouraged.
|Has Detail=Preclinicaltrials.eu is an international registration platform dedicated to animal studies that was launched in 2018 by a team of Dutch researchers. With several features, the platform permits a fast and efficient (pre)registration, data sharing, and collaboration:

*'''Free''' to access and use, with a '''short and focussed''' form to facilitate preregistration.
*Preregistration under embargo is available to protect '''privacy''' and '''intellectual property.''' Protocols also receive a time-stamp to prove '''authenticity'''.
*Track changed amendments are available to enable '''flexibility'''.
*Anonymised personal details and required login to view protocols ensure '''confidentiality'''.
*Protocol get a persistent identifier to use in grants or papers, which promotes '''FAIR data.'''
*Researchers from the same field or working on similar topics can reach each other via encrypted messages and form '''collaborations'''.

Moreover, preclinicaltrials.eu provides several resources to guide researchers with their preregistration.

To know more about this registry, you may check their introduction video: https://www.youtube.com/watch?v=xYjLvDBTsV4

More knowledge on how to use the platform can be seen on this walkthrough: https://www.youtube.com/watch?v=qLu1fXYumyk

For further information on preregistering at Preclinicaltrials.eu, you may check the registry's website: www.preclinicaltrials.eu or e-mail the Preclinicaltrials.eu team at info@preclinicaltrials.eu
}}
{{Related To
|Related To Theme=Theme:Bbf561cd-7369-4314-ac74-2c870373af9d
}}
{{Tags
|Involves=Julia Menon
|Has Virtue And Value=Openness; Transparency; Reliability
|Has Good Practice And Misconduct=Pre-registrations
|Related To Research Area=LS - Life Sciences
}}

Theme:30f90943-c3fc-4a8b-b01d-5a66288e3678

2021-07-14T15:43:49Z

0000-0002-3467-1908:

{{Theme
|Theme Type=Good Practices
|Has Parent Theme=Theme:7e07b7fa-793a-4282-a036-6fefe8480b3a
|Title=Preregistration of animal study protocols
|Is About=Preregistration is the act of registering research protocols before conducting the experiments. It enables to state in advance the type of study (exploratory or confirmatory), hypotheses, methodological design and statistical plan that are going to be used.

Preregistration of animal studies belongs to the Open Science movement and enables a comprehensive overview of all (registered) studies, including those that might otherwise remain unpublished. Therefore, it promotes transparency and research rigour.

Although this process is rather common in clinical research, it is not yet standard practice in the preclinical field. According to recent reviews, initiatives are present to promote preregistration of animal studie, but the uptake remains slow [1]

[1] Baker M. Animal registries aim to reduce bias. Nature. 2019;573(7773):297-8, doi:10.1038/d41586-019-02676-4
|Important Because=Preregistration prevents several biases often occurring in preclinical experiments and promote responsible & robust animal research. By reducing these biases, researchers increase the value and reliability of their studies and contribute to better science.

*The overview created by preregistration enables to '''counter publication bias''' by making these studies available regardless of their results.
*Preregistration enables to compare final publication and (pre)registered protocols, which '''increase transparency''' and '''reduce reporting bias''', such as selective outcomes reporting.
*By stating in advance hypotheses and statistical plans, preregistration '''reduces misconducts''' like HARKing (Hypothesis After Results are Known) and p-hacking.
*The free access of study protocols enables to verify which studies are or were conducted and hence permits to '''avoid unnecessary duplication''' of animal studies.
*Most preregistration forms request information linked to internal validity (e.g., randomisation, blinding, sample size calculation), which may impact '''study design robustness and reporting'''.
|Important For=All stakeholders in research
|Has Best Practice=The best practice is to preregister study protocols online in a registry. When describing their study designs, researchers should be as transparent and complete as possible.

To date, only two reliable animal registries are available:[https://preclinicaltrials.eu/ Preclinicaltrials.eu] and the [https://www.animalstudyregistry.org/asr_web/index.action Animal Study Registry].

It is also possible to use general registries, e.g. the Open Science Framework, however the registration forms will not be tailored to animal studies specifically.

If a study could not be preregistered, it is still worthwhile to register its protocol at a later stage; especially if the study could not be published. Although, prospective registration (i.e., registration before the experiments) should be encouraged.
|Has Detail=Preclinicaltrials.eu is an international registration platform dedicated to animal studies that was launched in 2018 by a team of Dutch researchers. With several features, the platform permits a fast and efficient (pre)registration, data sharing, and collaboration:

*'''Free''' to access and use, with a '''short and focussed''' form to facilitate preregistration.
*Preregistration under embargo is available to protect '''privacy''' and '''intellectual property.''' Protocols also receive a time-stamp to prove '''authenticity'''.
*Track changed amendments are available to enable '''flexibility'''.
*Anonymised personal details and required login to view protocols ensure '''confidentiality'''.
*Protocol get a persistent identifier to use in grants or papers, which promotes '''FAIR data.'''
*Researchers from the same field or working on similar topics can reach each other via encrypted messages and form '''collaborations'''.

Moreover, preclinicaltrials.eu provides several resources to guide researchers with their preregistration.

To know more about this registry, you may check their introduction video: https://www.youtube.com/watch?v=xYjLvDBTsV4

More knowledge on how to use the platform can be seen on this walkthrough: https://www.youtube.com/watch?v=qLu1fXYumyk

For further information on preregistering at Preclinicaltrials.eu, you may check the registry's website: www.preclinicaltrials.eu or e-mail the Preclinicaltrials.eu team at info@preclinicaltrials.eu
}}
{{Related To
|Related To Theme=Theme:Bbf561cd-7369-4314-ac74-2c870373af9d
}}
{{Tags
|Involves=Julia Menon
|Has Virtue And Value=Openness; Transparency; Reliability
|Has Good Practice And Misconduct=Pre-registrations
|Related To Research Area=LS - Life Sciences
}}

Theme:30f90943-c3fc-4a8b-b01d-5a66288e3678

2021-07-14T15:35:15Z

0000-0002-3467-1908:

{{Theme
|Theme Type=Good Practices
|Has Parent Theme=Theme:7e07b7fa-793a-4282-a036-6fefe8480b3a
|Title=Preregistration of animal study protocols
|Is About=Preregistration is the act of registering research protocols before conducting the experiments. It enables to state in advance the type of study (exploratory or confirmatory), hypotheses, methodological design and statistical plan that are going to be used.

Preregistration of animal studies belongs to the Open Science movement and enables a comprehensive overview of all (registered) studies, including those that might otherwise remain unpublished. Therefore, it promotes transparency and research rigour.

Although this process is rather common in clinical research, it is not yet standard practice in the preclinical field. According to recent reviews, initiatives are present to promote preregistration of animal studie, but the uptake remains slow [1]

[1] Baker M. Animal registries aim to reduce bias. Nature. 2019;573(7773):297-8, doi:10.1038/d41586-019-02676-4
|Important Because=Preregistration prevents several biases often occurring in preclinical experiments and promote responsible & robust animal research. By reducing these biases, researchers increase the value and reliability of their studies and contribute to better science.

*The overview created by preregistration enables to '''counter publication bias''' by making these studies available regardless of their results.
*Preregistration enables to compare final publication and (pre)registered protocols, which '''increase transparency''' and '''reduce reporting bias''', such as selective outcomes reporting.
*By stating in advance hypotheses and statistical plans, preregistration '''reduces misconducts''' like HARKing (Hypothesis After Results are Known) and p-hacking.
*The free access of study protocols enables to verify which studies are or were conducted and hence permits to '''avoid unnecessary duplication''' of animal studies.
*Most preregistration forms request information linked to internal validity (e.g., randomisation, blinding, sample size calculation), which may impact '''study design robustness and reporting'''.
|Important For=All stakeholders in research
|Has Best Practice=The best practice is to preregister study protocols online in a registry. When describing their study designs, researchers should be as transparent and complete as possible.

To date, only two reliable animal registries are available:[https://preclinicaltrials.eu/ Preclinicaltrials.eu] and the [https://www.animalstudyregistry.org/asr_web/index.action Animal Study Registry].

It is also possible to use general registries, e.g. the Open Science Framework, however the registration forms will not be tailored to animal studies specifically.

If a study could not be preregistered, it is still worthwhile to register its protocol at a later stage; especially if the study could not be published. Although, prospective registration (i.e., registration before the experiments) should be encouraged.
|Has Detail=Preclinicaltrials.eu is an international registration platform dedicated to animal studies that was launched in 2018 by a team of Dutch researchers. With several features, the platform permits a fast and efficient (pre)registration, data sharing, and collaboration:

*'''Free''' to access and use, with a '''short and focussed''' form to facilitate preregistration.
*Preregistration under embargo is available to protect '''privacy''' and '''intellectual property.''' Protocols also receive a time-stamp to prove '''authenticity'''.
*Track changed amendments are available to enable '''flexibility'''.
*Anonymised personal details and required login to view protocols ensure '''confidentiality'''.
*Protocol get a persistent identifier to use in grants or papers, which promotes '''FAIR data.'''
*Researchers from the same field or working on similar topics can reach each other via encrypted messages and form '''collaborations'''.

Moreover, preclinicaltrials.eu provides several resources to guide researchers with their preregistration.

To know more about this registry, you may check their introduction video: https://www.youtube.com/watch?v=xYjLvDBTsV4

More knowledge on how to use the platform can be seen on this walkthrough: https://www.youtube.com/watch?v=qLu1fXYumyk

For further information on preregistering at Preclinicaltrials.eu, you may check the registry's website: www.preclinicaltrials.eu or e-mail the Preclinicaltrials.eu team at info@preclinicaltrials.eu
}}
{{Related To
|Related To Theme=Theme:Bbf561cd-7369-4314-ac74-2c870373af9d
}}
{{Tags
|Has Virtue And Value=Openness; Transparency; Reliability
|Has Good Practice And Misconduct=Pre-registrations
|Related To Research Area=LS - Life Sciences
}}

Theme:30f90943-c3fc-4a8b-b01d-5a66288e3678

2021-07-14T15:30:29Z

0000-0002-3467-1908: Created page with "{{Theme |Theme Type=Good Practices |Has Parent Theme=Theme:D61666e2-58df-470f-bfb6-9f8ac2eea64f |Title=Preregistration of animal study protocols |Is About=Preregistration is t..."

{{Theme
|Theme Type=Good Practices
|Has Parent Theme=Theme:D61666e2-58df-470f-bfb6-9f8ac2eea64f
|Title=Preregistration of animal study protocols
|Is About=Preregistration is the act of registering research protocols before conducting the experiments. It enables to state in advance the type of study (exploratory or confirmatory), hypotheses, methodological design and statistical plan that are going to be used.

Preregistration of animal studies belongs to the Open Science movement and enables a comprehensive overview of all (registered) studies, including those that might otherwise remain unpublished. Therefore, it promotes transparency and research rigour.

Although this process is rather common in clinical research, it is not yet standard practice in the preclinical field. According to recent reviews, initiatives are present to promote preregistration of animal studie, but the uptake remains slow [1]

[1] Baker M. Animal registries aim to reduce bias. Nature. 2019;573(7773):297-8, doi:10.1038/d41586-019-02676-4
|Important Because=Preregistration prevents several biases often occurring in preclinical experiments and promote responsible & robust animal research. By reducing these biases, researchers increase the value and reliability of their studies and contribute to better science.

* The overview created by preregistration enables to '''counter publication bias''' by making these studies available regardless of their results.
* Preregistration enables to compare final publication and (pre)registered protocols, which '''increase transparency''' and '''reduce reporting bias''', such as selective outcomes reporting.
* By stating in advance hypotheses and statistical plans, preregistration '''reduces misconducts''' like HARKing (Hypothesis After Results are Known) and p-hacking.
* The free access of study protocols enables to verify which studies are or were conducted and hence permits to '''avoid unnecessary duplication''' of animal studies.
* Most preregistration forms request information linked to internal validity (e.g., randomisation, blinding, sample size calculation), which may impact '''study design robustness and reporting'''.
|Important For=All stakeholders in research
|Has Best Practice=The best practice is to preregister study protocols online in a registry. When describing their study designs, researchers should be as transparent and complete as possible.

To date, only two reliable animal registries are available:[https://preclinicaltrials.eu/ Preclinicaltrials.eu] and the [https://www.animalstudyregistry.org/asr_web/index.action Animal Study Registry].

It is also possible to use general registries, e.g. the Open Science Framework, however the registration forms will not be tailored to animal studies specifically.

If a study could not be preregistered, it is still worthwhile to register its protocol at a later stage; especially if the study could not be published. Although, prospective registration (i.e., registration before the experiments) should be encouraged.
|Has Detail=Preclinicaltrials.eu is an international registration platform dedicated to animal studies that was launched in 2018 by a team of Dutch researchers. With several features, the platform permits a fast and efficient (pre)registration, data sharing, and collaboration:

* '''Free''' to access and use, with a '''short and focussed''' form to facilitate preregistration.
* Preregistration under embargo is available to protect '''privacy''' and '''intellectual property.''' Protocols also receive a time-stamp to prove '''authenticity'''.
* Track changed amendments are available to enable '''flexibility'''.
* Anonymised personal details and required login to view protocols ensure '''confidentiality'''.
* Protocol get a persistent identifier to use in grants or papers, which promotes '''FAIR data.'''
* Researchers from the same field or working on similar topics can reach each other via encrypted messages and form '''collaborations'''.

Moreover, preclinicaltrials.eu provides several resources to guide researchers with their preregistration.

To know more about this registry, you may check their introduction video: https://www.youtube.com/watch?v=xYjLvDBTsV4

More knowledge on how to use the platform can be seen on this walkthrough: https://www.youtube.com/watch?v=qLu1fXYumyk

For further information on preregistering at Preclinicaltrials.eu, you may check the registry's website: www.preclinicaltrials.eu or e-mail the Preclinicaltrials.eu team at info@preclinicaltrials.eu
}}
{{Related To
|Related To Theme=Theme:Bbf561cd-7369-4314-ac74-2c870373af9d
}}
{{Tags
|Has Virtue And Value=Openness; Transparency; Reliability
|Has Good Practice And Misconduct=Pre-registrations
|Related To Research Area=LS - Life Sciences
}}

User:0000-0002-3467-1908

2021-07-12T14:49:39Z

0000-0002-3467-1908: create user page