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Interactive lecture on Gene editing: Exploring Ethical Challenges
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wiki page content language: en
display title: Interactive lecture on Gene editing: Exploring Ethical Challenges
has duration: 3
has requirements: '''For trainers:''' Before using this module trainers should complete the two ENERI e-learning modules on Gene Editing: [https://classroom.eneri.eu/node/306 Gene Editing: Ethics Issues] and [https://classroom.eneri.eu/node/221 Gene Editing: Technology Basics] '''For trainees:''' No prior expertise in gene editing is required, but participants should have a basic understanding of research ethics concepts. Participants are encouraged to complete the ENERI e-learning module on [https://classroom.eneri.eu/node/146 Research Ethics And Integrity Basics]
important for: Research Ethics Committee Member
instruction goal: This module introduces the ethical challenges in gene editing. Using real life cases, it aims to encourage reflection on ethical issues related to this technology.
main category: Category:Instruction
title: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki page creation date: 2025-02-04T16:03:57Z
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display title of: Interactive lecture on Gene editing: Exploring Ethical Challenges
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wiki page modification date: 2026-03-01T18:33:40Z
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master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
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instruction step text: *Ask each group to present their analysis (5 minutes per group, depending on the number of groups). *Facilitate a plenary discussion to connect insights to real-world practices. Ask participants about their own experiences, (e.g. related real life examples they want to share them with the group). *To prompt the discussion you can make use of the following questions: How did you experience the exercise? Did your view change? Do you see any similarities in real life experiences? Were you surprised by any particular point that was raised during the discussions?
instruction step title: Group presentations and plenary discussion (30-40 minutes)
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master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
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instruction step text: '''Introduce yourself and share the plan for the session presented below:''' *Ice-breaker *Short introductory lecture *Case discussion in smaller groups *Plenary discussion '''Introduce the ''Learning Objectives -'' after the session participants are able to:''' #''Weigh the potential harms and benefits of different areas of gene editing. '' #''Reflect upon some of the ethics issues (like dual use/misuse or long-term ethical and societal implications) associated with gene editing.'' #''Recognize ethical and safety concerns associated with gene editing techniques and their applications.'' '''Use a warm up question to introduce the topic:''' Use this as an interactive exercise before starting with the session. Ask participants one of these questions, encouraging participants to share their answers with the group: *''What’s one word that comes to mind when you think of gene editing?'' *''What's one aspect of gene editing that makes you feel excited or uneasy?'' '''Briefly introduce the topic:''' ''Gene editing is a transformative and evolving technology that has a big potential for addressing problems in healthcare, agriculture, among others. However, it also raises critical ethical questions since it can have severe societal and environmental long-term consequences. Since the CRISPR-Cas9 became a reality, many debates about human enhancement and justice issues regarding access to the technology have surrounded gene editing.'' ''This training session is designed to equip participants with the knowledge and tools to navigate the complex ethical issues that arise from gene editing. By exploring and discussing real cases, participants will develop a deeper understanding of the challenges and responsibilities associated to gene editing.'' '''Trainer Tip:''' Use this moment to create a '''welcoming''' and '''open''' environment, emphasizing that the session wants to '''encourage ethical reflection''' in an open and '''safe''' space.
instruction step title: Welcome (10-15 minutes) & introduction of the session program and objectives
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master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
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has practical tips: *Familiarize yourself with the irecs materials on gene editing and identify where are the videos and cases you will use for this session *Test all digital tools (Mentimeter, digital whiteboards) in advance. *Be aware of the diverse cultural and regulatory backgrounds of the trainees in your group. *Share additional resources and the rest of e-modules at the end of the session. *Collect feedback through the evaluation form to improve future sessions.
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master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
instruction step text: '''Introduce yourself and share the plan for the session presented below:''' *Ice-breaker *Short introductory lecture *Case discussion in smaller groups *Plenary discussion
instruction step title: Welcome (10-15 minutes) & introduction of the session program and objectives
wiki page sort key: 1

http://https://embassy.science:443/wiki/Special:URIResolver/Instruction-3AD51b8272-2D661c-2D49eb-2D875a-2D13da8a955df5-23_32560d65065dc2c5133d72d5c2efa079
type: Subject
type: Category:Instruction Step Trainee
master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
instruction step text: *Present the irecs video on the CRISPR-Cas9 case of Lulu and Nana. You can find it here: [https://classroom.eneri.eu/node/308 A Case Of Gene Editing In Human Embryos] *After the video, have a brief discussion by asking participants the following questions: What are the main ethical issues in this case? How do these issues relate to societal or regulatory concerns? '''Trainer Tip:''' Allow for a brief open discussion but '''keep it focused''' to ensure you stay within the allocated time.
instruction step title: Warm up: Case presentation (15 minutes)
wiki page sort key: 3

http://https://embassy.science:443/wiki/Special:URIResolver/Instruction-3AD51b8272-2D661c-2D49eb-2D875a-2D13da8a955df5-23_c0611d48a8e1680e371bfef291c3489b
type: Subject
type: Category:Instruction Step Trainee
master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
instruction step text: Discuss core ethical concepts related to gene editing, applying the concepts to practical cases. To build your presentation you can use the content of the irecs modules, which will provide you with videos and examples. For more engagement, you can ask participants to select one of the following topics and focus on it in depth: '''A) Gene editing in embryos→''' key concepts: moral status of embryos, human enhancement, risk/benefit, autonomy and beneficence. Resources: #Matching exercise on gene editing in human embryos and its associated ethical issues: [https://classroom.eneri.eu/node/310 Germline Gene Editing.] #Explanation of germline gene editing: [https://classroom.eneri.eu/node/310 Germline Gene Editing.] #Explanation of gene editing in human embryos: [https://classroom.eneri.eu/node/311 Gene Editing And Human Embryos] '''B) Gene editing justice and equality→''' key concepts: risk/benefits ratio, costs/benefits of gene therapy, patents gains, global considerations, medical need vs. human enhancement, socioeconomic inequalities, inclusion and stigma of people with disabilities. #Introduction to gene editing and equality issues: [https://classroom.eneri.eu/node/314 Gene Editing, Justice, And Equality] #Potential benefits and risks of gene editing in terms of justice and equality: [https://classroom.eneri.eu/node/315 Gene Editing, Justice, And Equality cont.] #Benefits and financial gains of CRISPR-Cas9: [https://classroom.eneri.eu/node/316 Who Profits Financially From CRISPR-Cas9?] '''C) Gene editing, dual use and non-human use→''' key concepts: dual use, risk/benefit of gene editing, non-human gene editing, environmental impacts, food safety. #Introduction to gene editing misuses and dual use: [https://classroom.eneri.eu/node/317 Gene Editing, Misuse, And Dual Use] #Environmental impacts of gene editing: [https://classroom.eneri.eu/node/318 Ethical Challenges For Non-Human Gene Editing] #Overview of the challenges related to agriculture and food safety of gene e…
instruction step title: Interactive lecture (45 minutes)
wiki page sort key: 4

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type: Subject
master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
has practical tips: *Familiarize yourself with the irecs materials on gene editing and identify where are the videos and cases you will use for this session *Test all digital tools (Mentimeter, digital whiteboards) in advance. *Be aware of the diverse cultural and regulatory backgrounds of the trainees in your group. *Share additional resources and the rest of e-modules at the end of the session. *Collect feedback through the evaluation form to improve future sessions.
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type: Subject
type: Category:Instruction Step Trainer
master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
instruction step text: The aim of this activity is to invite participants to '''reflect''' on their '''expectations'''. This is useful both for trainers and participants. '''Trainers can pick between two possible activities:''' '''OPTION 1:''' ''Mind map activity → small group activity: in sub-groups participants create a mind map of their current knowledge on the topic.'' The following steps can support trainers in organizing this activity: *Divide participants into subgroups. *Provide each group with a digital (or physical) board. *Ask them to brainstorm and write down the words that come to mind when they think of "gene editing." *Ask them to divide the terms into: -Topics they want to learn more about. -Topics they are already familiar with. *After 6-7 minutes of discussion in sub-groups, ask all groups share their maps with the group. Together with the group select the most common unknown topics. '''OPTION 2:''' ''Learning goals with Mentimeter'' *Prepare and share a Mentimeter (or similar tool) with the following question: ''after this session I expect to be able to…'' *Ask participants to submit two goals, project the results and discuss them with the group.
instruction step title: Ice breaker (10 minutes)
wiki page sort key: 2

http://https://embassy.science:443/wiki/Special:URIResolver/Instruction-3AD51b8272-2D661c-2D49eb-2D875a-2D13da8a955df5-23_66e16701e8056df553c8da51393b2698
type: Subject
type: Category:Instruction Step Trainer
master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
instruction step text: *Present the irecs video on the CRISPR-Cas9 case of Lulu and Nana. You can find it here: [https://classroom.eneri.eu/node/308 A Case Of Gene Editing In Human Embryos] *After the video, have a brief discussion by asking participants the following questions: What are the main ethical issues in this case? How do these issues relate to societal or regulatory concerns? '''Trainer Tip:''' Allow for a brief open discussion but '''keep it focused''' to ensure you stay within the allocated time.
instruction step title: Warm up: Case presentation (15 minutes)
wiki page sort key: 3

http://https://embassy.science:443/wiki/Special:URIResolver/Instruction-3AD51b8272-2D661c-2D49eb-2D875a-2D13da8a955df5-23_2266725fe2602aa98fccfc5ef598877f
type: Subject
type: Category:Instruction Step Trainer
master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
instruction step text: Discuss core ethical concepts related to gene editing, applying the concepts to practical cases. To build your presentation you can use the content of the irecs modules, which will provide you with videos and examples. For more engagement, you can ask participants to select one of the following topics and focus on it in depth: '''A) Gene editing in embryos→''' key concepts: moral status of embryos, human enhancement, risk/benefit, autonomy and beneficence. Resources: #Matching exercise on gene editing in human embryos and its associated ethical issues: [https://classroom.eneri.eu/node/310 Germline Gene Editing.] #Explanation of germline gene editing: [https://classroom.eneri.eu/node/310 Germline Gene Editing.] #Explanation of gene editing in human embryos: [https://classroom.eneri.eu/node/311 Gene Editing And Human Embryos] '''B) Gene editing justice and equality→''' key concepts: risk/benefits ratio, costs/benefits of gene therapy, patents gains, global considerations, medical need vs. human enhancement, socioeconomic inequalities, inclusion and stigma of people with disabilities. #Introduction to gene editing and equality issues: [https://classroom.eneri.eu/node/314 Gene Editing, Justice, And Equality] #Potential benefits and risks of gene editing in terms of justice and equality: [https://classroom.eneri.eu/node/315 Gene Editing, Justice, And Equality cont.] #Benefits and financial gains of CRISPR-Cas9: [https://classroom.eneri.eu/node/316 Who Profits Financially From CRISPR-Cas9?] '''C) Gene editing, dual use and non-human use→''' key concepts: dual use, risk/benefit of gene editing, non-human gene editing, environmental impacts, food safety. #Introduction to gene editing misuses and dual use: [https://classroom.eneri.eu/node/317 Gene Editing, Misuse, And Dual Use] #Environmental impacts of gene editing: [https://classroom.eneri.eu/node/318 Ethical Challenges For Non-Human Gene Editing] #Overview of the challenges related to agriculture and food safety of gene e…
instruction step title: Interactive lecture (45 minutes)
wiki page sort key: 4

http://https://embassy.science:443/wiki/Special:URIResolver/Instruction-3AD51b8272-2D661c-2D49eb-2D875a-2D13da8a955df5-23_528fdf8487134405c0fa9f604f720a5b
type: Subject
type: Category:Instruction Step Trainer
master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
instruction step text: Introduce a case. The case must be related to the concepts selected and presented during the interactive lecture. Therefore, if only one of the topics was covered, the case should be related to that topic. Below, some case examples are presented. Note that justice issues appear in both cases: *'''Case related to topic A&B''': ''The ISSCR suggests that studies proposing to grow human embryos beyond two weeks should be considered on a case-by-case basis. Imagine that you are a member of a committee that has been asked to approve a study that involves gene editing of embryos that will be grown for 28 days. How would you go about this, and what sort of things might you include in your deliberations? Would you approve this study?'' (case extracted from: [https://classroom.eneri.eu/node/312 Reflection Activity]) *'''Case related to topic C&B''': ''Imagine you are on an ethics committee reviewing a research proposal to produce genetically modified mosquitoes to combat malaria. This would releasing gene-edited organisms into a natural ecosystem in Sub-Saharan countries mostly. As an ethics expert, what criteria would you use to assess this proposal? How would you balance the potential health benefits with ethical concerns around environmental impact, dual-use, etc.?'' (case extracted from: [https://classroom.eneri.eu/node/387 A case of non-human gene editing]) '''Instructions for trainer:''' *Present the case (10 minutes). In case you need more information, you can retrieve it from the ENERI modules. Take into account the amount of time you have for this exercise. It is advised to project slide with the case, so participants can look at it during the group discussion. *Divide participants into subgroups (4-5 members). You can provide each group with a white board/digital board. *Provide participants with the following instructions for the subgroup discussion: '''a.''' Read the case carefully and reflect on it individually (10 minutes). Ask yourself: What is important to you…
instruction step title: Case discussion in subgroups (45 minutes)
wiki page sort key: 5

http://https://embassy.science:443/wiki/Special:URIResolver/Instruction-3AD51b8272-2D661c-2D49eb-2D875a-2D13da8a955df5-23_7dffa000682e9ce165ef112e26c1e9f0
type: Subject
type: Category:Instruction Step Trainer
master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
instruction step text: *Return to the icebreaker activity or learning goals (mind mapping or Mentimeter results) and ask participants if their expectations were met. *Share a QR code linking to the evaluation form and online modules for continued learning. *Thank participants for their contributions and encourage them to apply their insights in their work and spread the word about the irecs modules.
instruction step title: Concluding session (10-20 minutes)
wiki page sort key: 7

http://https://embassy.science:443/wiki/Special:URIResolver/Instruction-3AD51b8272-2D661c-2D49eb-2D875a-2D13da8a955df5-23_8e067c590ecf8750bf08383c21708010
type: Subject
type: Category:Instruction Step Trainee
master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
instruction step text: Introduce a case. The case must be related to the concepts selected and presented during the interactive lecture. Therefore, if only one of the topics was covered, the case should be related to that topic. Below, some case examples are presented. Note that justice issues appear in both cases: *'''Case related to topic A&B''': ''The ISSCR suggests that studies proposing to grow human embryos beyond two weeks should be considered on a case-by-case basis. Imagine that you are a member of a committee that has been asked to approve a study that involves gene editing of embryos that will be grown for 28 days. How would you go about this, and what sort of things might you include in your deliberations? Would you approve this study?'' (case extracted from: [https://classroom.eneri.eu/node/312 Reflection Activity]) *'''Case related to topic C&B''': ''Imagine you are on an ethics committee reviewing a research proposal to produce genetically modified mosquitoes to combat malaria. This would releasing gene-edited organisms into a natural ecosystem in Sub-Saharan countries mostly. As an ethics expert, what criteria would you use to assess this proposal? How would you balance the potential health benefits with ethical concerns around environmental impact, dual-use, etc.?'' (case extracted from: [https://classroom.eneri.eu/node/387 A case of non-human gene editing]) '''Instructions for trainer:''' *Present the case (10 minutes). In case you need more information, you can retrieve it from the ENERI modules. Take into account the amount of time you have for this exercise. It is advised to project slide with the case, so participants can look at it during the group discussion. *Divide participants into subgroups (4-5 members). You can provide each group with a white board/digital board. *Provide participants with the following instructions for the subgroup discussion: '''a.''' Read the case carefully and reflect on it individually (10 minutes). Ask yourself: What is important to you…
instruction step title: Case discussion in subgroups (45 minutes)
wiki page sort key: 5

http://https://embassy.science:443/wiki/Special:URIResolver/Instruction-3AD51b8272-2D661c-2D49eb-2D875a-2D13da8a955df5-23_e6777a5ab889496c13ab87d55d4368ee
type: Subject
type: Category:Instruction Step Trainee
master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
instruction step text: *Ask each group to present their analysis (5 minutes per group, depending on the number of groups). * *Facilitate a plenary discussion to connect insights to real-world practices. Ask participants about their own experiences, (e.g. related real life examples they want to share them with the group). *To prompt the discussion you can make use of the following questions: How did you experience the exercise? Did your view change? Do you see any similarities in real life experiences? Were you surprised by any particular point that was raised during the discussions?
instruction step title: Group presentations and plenary discussion (30-40 minutes)
wiki page sort key: 6

http://https://embassy.science:443/wiki/Special:URIResolver/Instruction-3AD51b8272-2D661c-2D49eb-2D875a-2D13da8a955df5-23_61bf6e93cd223eecd520928d9c096b62
type: Subject
type: Category:Instruction Step Trainee
master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
instruction step text: The aim of this activity is to invite participants to '''reflect''' on their '''expectations'''. This is useful both for trainers and participants. '''Trainers can pick between two possible activities:''' '''OPTION 1:''' ''Mind map activity → small group activity: in sub-groups participants create a mind map of their current knowledge on the topic.'' The following steps can support trainers in organizing this activity: *Divide participants into subgroups. *Provide each group with a digital (or physical) board. *Ask them to brainstorm and write down the words that come to mind when they think of "gene editing." *Ask them to divide the terms into: -Topics they want to learn more about. -Topics they are already familiar with. *After 6-7 minutes of discussion in sub-groups, ask all groups share their maps with the group. Together with the group select the most common unknown topics. '''OPTION 2:''' ''Learning goals with Mentimeter'' *Prepare and share a Mentimeter (or similar tool) with the following question: ''after this session I expect to be able to…'' *Ask participants to submit two goals, project the results and discuss them with the group.
instruction step title: Ice breaker (10 minutes)
wiki page sort key: 2

http://https://embassy.science:443/wiki/Special:URIResolver/Instruction-3AD51b8272-2D661c-2D49eb-2D875a-2D13da8a955df5-23_d8237cacfa7c156bd0b3c27b67cb1462
type: Subject
type: Category:Instruction Step Trainee
master page: Interactive lecture on Gene editing: Exploring Ethical Challenges
wiki namespace: 7800
instruction step text: *Return to the icebreaker activity or learning goals (mind mapping or Mentimeter results) and ask participants if their expectations were met. * * *Share a QR code linking to the evaluation form and online modules for continued learning. * *Thank participants for their contributions and encourage them to apply their insights in their work and spread the word about the irecs modules.
instruction step title: Concluding session (10-20 minutes)
wiki page sort key: 7

IRECS Training format (template)
type: Subject
page: https://embassy.science:443/wiki/Instruction-3A9fb3101c-2D3f39-2D47c6-2D9db1-2Db0b5ad66d1ab
wiki namespace: 7800
wiki page content language: en
wiki page sort key: IRECS Training format (template)

http://https://embassy.science:443/wiki/Special:URIResolver/Guide-3A999afd1a-2Dd200-2D4cff-2D952b-2D2b4daa735474-23_caa775e449e63c904787b34bf2a57c9f
type: Subject
master page: http://https://embassy.science:443/wiki/Special:URIResolver/Guide-3A999afd1a-2Dd200-2D4cff-2D952b-2D2b4daa735474
wiki namespace: 7900
wiki page sort key: IRECS trainer guide# caa775e449e63c904787b34bf2a57c9f# caa775e449e63c904787b34bf2a57c9f

Related To Object
type: ObjectProperty
page: https://embassy.science:443/wiki/Property-3ARelated_To_Object
wiki namespace: 102
wiki page content language: en
wiki page sort key: Related To Object

Related Instructions
type: ObjectProperty
page: https://embassy.science:443/wiki/Property-3ARelated_To_Instruction
wiki namespace: 102
wiki page content language: en
wiki page sort key: Related To Instruction
type: wpg

Element
type: ObjectProperty
page: https://embassy.science:443/wiki/Property-3AGuide_Step_Element
wiki namespace: 102
wiki page content language: en
wiki page sort key: Guide Step Element
type: wpg