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- Prospective registration of clinical trials + (In 2004, the International Committee of Me … In 2004, the International Committee of Medical Journal Editors (ICMJE) announced that clinical trials beginning after July 1, 2005, would be under a new trial registration policy. '"`UNIQ--ref-00000093-QINU`"' To be published in member journals, the trials would have to be registered in an approved trial registry prior to the enrollment of the first participant. Since 2005, ICMJE has reiterated that registering a prospective study should be a condition of publication and after the announcement, several journals endorsed this policy. The registration must occur prior to enrollment of the first study participant in a trial registry that meets the quality criteria developed by WHO. '"`UNIQ--ref-00000094-QINU`"' However, the adherence for this requirement remains low by both researchers and journal editors and, unfortunately, not all clinical trials are registered before they start.</br></br>Recent findings suggest that among the reasons that lead to the low adherence to the new requirement by the researchers are: lack of awareness of the criteria; misunderstandings regarding the definition of clinical trial by ICMJE; and difficulties for registration. '"`UNIQ--ref-00000095-QINU`"' On the part of journal editors, the main reason is that not all journals are equally committed to meeting the registration requirements, strengths, and limitations of the study. The Committee on Publication Ethics suggested that “it is probably best to judge each paper on a case by case basis.”</br>'"`UNIQ--references-00000096-QINU`"'sis.” '"`UNIQ--references-00000096-QINU`"')
