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- Inappropriate study design + (Observational studies, such as cohort or c … Observational studies, such as cohort or case – control studies, are sometimes overinterpreted in terms of cause-effect relationship. Correlation between a factor and an outcome does not necessarily mean causation. When it comes to experimental studies, sometimes randomization is not possible due to ethical reasons which should be taken in account when interpreting results of such studies. '"`UNIQ--ref-0000025F-QINU`"' Sometimes outcome measures do not correspond completely to questions asked in the study i.e. they are only indirectly connected.</br></br>All of this is usually addressed in research methodology classes. When planning, doing and reporting research, you can always rely on appropriate EQUATOR reporting guidelines to make sure you have everything accounted for.</br>'"`UNIQ--references-00000260-QINU`"' for. '"`UNIQ--references-00000260-QINU`"')